JOB DESCRIPTION
Our group is a multidisciplinary team that carries out both translational and clinical research as we are members of the Genetics Department and the Clinical Pharmacogenomics group. In particular, we, the Clinical Genomics Research group focuses on the development of new tools for genetic diagnosis and also on building the foundations of a personalized strategy for Neurofibromatosis and Schwannomatosis. We are also discovering new prognostic biomarkers, understanding the role of genomic alterations in the development of disease-associated lesions, and implementing various gene therapy strategies to cure these diseases. Furthermore, we participate on the Spanish Reference Center (CSUR) for patients with Phakomatoses (Neurofibromatoses, Schwannomatosis, Tuberous Sclerosis, and Von-Hippel Lindau diseases), which is a part of the European Network of Reference Centers (ERN) GENTURIS. Currently we are also the coordinators of international Variant Curation Expert Panel (VCEP) for Neurofibromatoses and Schwannomatosis by ClinGen (NIH) to stablish the variant classification ACMG rules for the genes causing these diseases.
We are currently participating in a national project to determine the clinical utility of analyzing different polymorphisms to reduce side effects and improve adherence to certain drugs (pharmacogenomics) from mass genotyping (IPHARMDX (IMPACT pharmacogenomics)) within the clinical pharmacogenomics working group. Our lines of research are: 1) development of new methodologies to improve current genomic testing; 2) massive genotyping to establish the personalized risk of specific diseases (Polygenic Risk Score) or adverse reactions to certain drugs (pharmacogenomics); among others.
In addition, we are also coordinating the European project EJPRD_NF to improve the genetic testing and variant classification for Neurofibromatosis type 1 and Schwannomatosis by applying new genomic technologies and also by the use of iPSC-derived cell models.
We are looking for an organized and motivated research assistant who is team-oriented and has previous experience with molecular biology (e.g., PCRs, sequencing, Western blots), genetics, and cell cultures. The ideal candidate will have a desire to work in a multidisciplinary team focused on clinical genetics and translational research. The main project in which the candidate would participate is in pharmacogenomics and PRS, although participation in the group's other projects is expected. If the candidate is interested, the possibility of pursuing a Ph.D. could be evaluated.
MAIN RESPONSIBILITIES
- As a member of the Clinical Pharmacogenomics Unit, you will participate in the various ongoing projects in the laboratory, research activities and publications, but primarily in carrying out the different high-throughput genotyping projects and other cellular and molecular biology techniques.
- You will actively assist in and implement new protocols to improve the genomic diagnostic techniques available in the laboratory, participate in research activities within the clinical genomics group, and contribute to team research publications.
- You will work daily as part of a multidisciplinary team with clinical staff, bioinformaticians, biologists and molecular geneticists.
- You will interact with experts in medicine, pharmacy, genetics and bioinformatics to jointly evaluate different project designs, protocols, results obtained, etc., participating in regular group meetings to understand clinical and research needs and to improve the required experiments.
If the candidate is interested, the possibility of pursuing a Ph.D. could be evaluated.
HOW TO APPLY
Interested persons must attach to the application:
- Motivation letter explaining their interest in the position.
- Updated CV.
- Contact of 2-3 references.
Applications will be evaluated in accordance with the guiding principles and objectives of the supply systems, following the process described below:
- Curricular evaluation: analysis of the curriculum vitae to assess aspects related to training, professional career and experience in positions related to the job position under selection.
- Personal interview: once the résumé has been evaluated, the selected candidates will be called for a personal interview to verify and expand on the information detailed in the résumé and to evaluate aspects related to experience and professional skills.
Applications that do not meet the requirements, that are not included in the cases foreseen or that are not processed in accordance with the established procedure will not be considered in the selection process.
DEADLINE FOR APPLICATIONS
The call for applications will close on November, 30th
About us
The Germans Trias i Pujol Research Institute (IGTP) is a public research centre located in Badalona. Its main objective is to increase scientific knowledge in order to transform it into solutions to improve the health and medical care of patients and the community.
The Institute is associated with one of the major university hospitals in the Barcelona area, the Germans Trias i Pujol Hospital, and is part of the Can Ruti biomedical campus. IGTP is a CERCA centre and is also accredited as a centre of excellence by the Instituto de Salud Carlos III (ISCIII) and is in charge of coordinating the management and scientific strategy of the campus, working in close collaboration with the other centres.
The Germans Trias i Pujol Research Institute carries out research within 9 areas:
- Cancer
- Cardiovascular and Respiratory Diseases
- Community Health
- Diseases of the Liver and Digestive Tract
- Endocrine and Diseases of the Metabolism, Bones and Kidneys
- Immunology and Inflammation
- Infectious Diseases
- Neuroscience
- Science of Behaviour and Substance Abuse
Scientists working in these areas publish an average of over 900 papers a year, contribute to improved treatment and healthcare protocols, produce patents and set up spin-off companies in order to improve the lives of patients.
The following video is a bird's eye view of Campus Can Ruti a top-tier translational research environment in the Barcelona area, in a very stimulating scientific environment. The IGTP offers a supportive, friendly and collaborative ecosystem to promote professional development and help you achieve your research goals.
The IGTP, in its commitment to equal opportunities, guarantees equal treatment between candidates and persons with a degree of disability equal to or greater than 33 per 100, as accredited by the Spanish Autonomous Regions or the State Administration, or who have been declared to have a total permanent disability in a different profession through a resolution of the National Institute of Social Security, while retaining functional capacity for the completion of the tasks of the post will be positively considered.
